Publications of Faculty of Medicine:RELATIONOF CHLAMYDIAPNEUMONIAE IgM& IgG,HELICOBACTERPYLORI IgG, SERUMINTERLEUKIN 6ANDCRP IN PATIENTSWITHCRESENDO UNSTABLE ANGINAANDACUTEMYOCARDIAL INFARCTION: Abstract

The effect of infection by Chlamydia pncumoniae (C. pneumoniae) and Helicobacter pylori (H. pylori) on patients with coronary heart diseases (CHD) was investigated. 50 patients, 25 had acute myocardial infarction (AMI) (Group I) and 25 had cresendo unstable angina (Group II) were selected as patient groups. 20 clinically healthy persons of the same age were selected as a control group (Group III). The patient groups were subgrouped according to the most important risk factors for CHD (smoking, hypertension, hypercholesterolaemia, and high triglycerides ). The level of C.pneumoniae IgG&IgM,H.pylori IgG ,IL6 andCRP were estimated in the sera of the three groups. It was found that C.pneumoniae IgGwas positive in 88%, 72%, and 35 %in groups I, II, and HI (respectively )which was significantly higher in group I and II than in group III. C.pneumoniae IgM was positive in 4%, 20% and 0% in groups I, II, and III( respectively) which was significantly higher in group I and II than group HI with a statistical significance among the three groups. H.pylori IgGwas positive in 60%, 48%, and 45% in groups I, II, and III (respectively) with insignificant difference among the three groups. As regards to smoking status, C.pneumoniae IgG was higher in smokers than in non smokers in groups Land II with significant difference in group I only, while C.pneumoniae IgMwas insignificant in both groups. H.pylori IgGwas high in smokers in group I (86.7%) than in groupll (52.9%) with non significant difference. Concerning blood pressure, C.pneumoniae IgG, IgMand H.pylori IgG in both groups were high in hypertensives with insignificant relation among them. As regards to cholesterol and triglycerides levels, C.pneumoniae IgG ,IgM and H.pylori IgG were high in patients with high levels of cholesterol and triglycerides in both patients groups with insignificant relation among them. IL6 and CRP were significantly elevated in groups I and II particularly in patients with serological evidence of C.pneumoniae.We concluded that, blocking the activity of IL0 might result in a decrease in acute coronary syndrome severity and can be viewed in light of a reduction in cardiovascular events in unstable angina and in survivors ofmyocardial infarction after antibiotic treatment for C.pneumoniae.