Objectives: To test the safety of sildenafil in patients with stable coronary artery disease
(CAD).
Methods: Sixty-one patients with stable CAD, documented by coronary angiography were
included in this phase I study. Patients were randomized to either single dose sildenafil or matched
placebo. Speckle tracking echocardiography was done at baseline and 60min after sildenafil/pla
cebo intake to calculate peak systolic strain (PSS) of themost severely affected myocardial segments
and the global longitudinal PSS. |
