Aim: to study the insulin resistance, hyperinsulinemia and coronary heart disease in patients with type
IT DM. Patients and methods: Twenty patients with type II DMand chronic stable angina (group A)
were compared to matched twenty patients with DMand there is no ischemic heart disease (group B)
using lab. Evaluation of insulin resistance by HOMA equation, lipid profile, plasma fibrinogen
between two groups and coronary angio (to group A only). Results: There were 16 patients with
insulin resistant in group A while it were 4 patients in group B, as regard, lipid profile there were
significant difference between two groups except to T.G. and also significant difference as regards
fibrinogen. We did coronary angio to group A and then we reclassifted as regard insulin resistance
subgroup and insulin sensitive subgroup. We found single vessel disease in 3 patients, two vessels
diseases in 4 patients and three vessel disease in 4 patients out of 16 patients in insulin resistance
subgroup while it were 4 patient with single vessel disease in insulin sensitive subgroup out of 4
patients. Conclusion: Insulin resistance in DMneeds clinical and biochemical investigation and there
is high association between insulin resistance and CAD also there is strong positive correlation
between severity ofCAD and degree of insulin resistance. |
