In order to clarify the association between antibodies to phospholipidbinding
plasmaprotein particularly; BZ-glycoprotein I, protein C and pro
tein S and fhrombotic complications in systemic lupus erythematosus pa
tients (SLE), 42 patients with SLE were selected and 10 healthy subjects
were also included as acontrolgroup, their age and sexmatched with
ourpatients. The Anti phospholipid antibodies (APLAbsj were measured
by an Enzyme Linked Immunosorbant Assay (EIJSA) system. The thrombotic
eventswere determined by venography, Adenography, Dopier ultra
sound, computed tomography (CD and magnetic resonant image (MIR).
Our result showed that all types oflgGAPLAbs were detected in SLEpa
tients (30%for anti-B2-Glycoprotein I, 21%for anti-protein C and 28%for
anti-protein S). thrombotic events were detected in 12 ofSLE patients (7
arterial and 5 venous). The prevalence ofLA and aCLwere significantly
higher in SLE patients with thrombosis than in those without thrombosis
(P < 0.01), but there was nan significant change between the prevalence
ofLA and aCL in patients with arterial and venous thrombosis (P > 0.05).
Concentration and prevalence of anti-B2-GPI was significantly higher in
patients with arterial thrombosis than in thosewith venous thrombosis (P
< 0.01). The concentration and prevalence of anti-protein C and antiprotein
S Abs were significantly higher in patients with venous thrombo
sis than in those with arterial thrombosis (P < 0.01). |
