The host protection either completely or partially is the main
goal of host vaccination against infection. .
This Study reports that the peak of humoral immune response is
achieved 7 weeks post —vaccination among SWAP(Soluble Worm
Antigen Preparation) vaccinated mice, then declines.
There are insignificant variations of humoral immune response
( Anti — SWAP IgE ,IgM and IgG ) among SWAP vaccinated ,
challenged mice and among control infected mice, but antibody /
antigen ratio is significantly higher ( Z value > 1.96 ) among SWAP
vaccinated , challenged mice than that among control infected mice
when antibody induced in a ratio with the count of worm burden (
38.6 ±5.5 _),( 74.2 ±9.9) respectively.
Praziquantel ( PZQ) therapy , often temporarly, increases the
humoral immune response 4 weeks after treatment.
SWAP vaccination significantly decreases worm burden 48%
(protection percentage ) among SWAP vaecinated challenged mice
than that in control infected mice which indicates on partial
protection against schistosomiasis.
This result represent the role of humoral response as one factor
for induction of partial protection (acquired resistance ) and further
studies are needed for the other factors which are responsible and
sharing in the acquired resistance against schistosomiasis. |
