Publications of Faculty of Medicine:Short termeffects of sildenafil citrate therapy in secondary pulmonary hypertension: Abstract

Title:
Short termeffects of sildenafil citrate therapy in secondary pulmonary hypertension
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Abstract:

Objectives: To study the short term effects of sildenafi] citrate therapy in patients with secondary pulmonary hypertension. Methods: Forty patients with known symptomatic secondary pulmonary hypertension due to val vular heart disease, chronic thromboembolic disease, chronic obstructive pulmonary disease, inter stitial pulmonary fibrosis, and idiopathic dilated cardiomyopathy were included in this phase II study. Patients were allocated in a randomized, placebo controlled design to either sildenafil or pla cebo for 6 weeks. Baseline and 6 week follow up included assessment of hemodynamic parameters, functional class using the NYHA classification, echocardiograpbic measurements of pulmonary artery systolic pressure and left ventricular ejection fraction