Thirty asymptomatic normotensive obese subjects, body mass index
03M1) > 30 kg/m2 (14+46.7%) males, 16 (53.3%) females, mean age 32.9
+6.5 years) and 20 well matched healthy lean control subjects (9(45%)
males, 11(5596) females, mean age 31.3 + 5.2 years) underwent an echo-
Doppler study to evaluate the effects of obesity on systolic as well as on
diastolic function. There was no significant difference in heart rate (HR),
systolic or diastolic blood pressure (SBP,DBP) between both groups
(P=NS). When compared with the lean group, the obese group exhibited a
significantly greater end-diastolic diameter (EDD) (4.9+0.2 Vs 4.4+0.3,
P<0.01), end diastolic volume (ED'!) (125.5±28 Vs 92.5+27 P<0.01), stroke
volume (SW (83.4+19 VS 59.6+17, P<0.01).Cardiac output (CO) (5.9+1.1
VS 4 .1+0.9, P<0.01), left atrial diameter (IA) (3.7+3.1Vs 3.2+2.8,P<0.01),
posterior wall thickness (PWT) (1.1+0.7Vs 0.81±0.6, P<0.01) and left ventricular
mass index (LVNII)(153+24V594+26, P<0.01). There was no significant
difference in end-systolic diameter (ESD), end-systolic volume (ESV),
septa' wall thickness (SWT), percentage of fibre shortening (FS) and ejection
fraction (EP) between both groups (13:--NS). Pulsed wave Doppler
echocardiographic filling indices were used to evaluate left ventricular
(LV) diastolic filling. The obese group had a significantly higher peak velocity
of atrialfilling (A velocity ) (57 ± 14 Vs 49±13, Pc 0.01), early / atrial
filling velocity ratio (E/ A ratio)(1.21 + 0.25 Vs 1.46-1-0.21, P<0.01), time
velocity integral of atrial filling velocity (Ai) (4.6±1.7V5 3.2±1.1, P<0.01)
and percentage of atrial contribution to total ventricular filling (96AC)(33±6
Vs 24±3,P<0.01). Peak early filling velocity (E- velocity) was insignificantly
lower in the obese group than the control group (P-NS), insignificant
prolongation of the deceleration time of peak early filling velocity (E-dec.)
(P=NS)and insignificantly higher time velocity integral of early filling velocity
(Ei) and total time velocity integral (Tvi)(P=NS).Correlation studies revealed
that the Bill was significantly correlated with Al and 96 AC (r=
0.62, P<0.05) and (r= 0.48,P<0.01) respectively. |
