Adult male rats were treated with clomiphene citrate, a non steroidal
inhibitor of gonad otropin release in the rats. They were administered orally
as 3.5rrtg/ 100g / day for period of 8 weeks. The weights of testis were
less than those of control animals, and the loss in weight progressed with
the duration of treatment. Microscopic alterations in the testis included a
scanty or even absence of late spematides, and accumulation of lipid
droplets. In rats treated for 8 weeks, testicular changes were even more
extensive, with evident degenerating primary spermatocytes |
