Acute renal failure (ARE) has been experimentally induced in rats using
50% glycerol in saline (10 ml/ kg LM.). The protective activity of carvedilol
on the induced ARE was examined at a dose of 2.25 mg/kg B. W.
The drug was administered orally, once daily for 3 consecutive days.
The results has revealed that the injection of glycerol was able to induce
a significant (P(0.05) elevation in serum levels of urea nitrogen, creatinine.
No+ and K+ ions. In additions to the marked eleziation of renal tissue
contents of nitrite (NO2-) and nitrate (NO3--) compared to the normal
values in the control animals.
The carvedilol pretreatment of rats with ARE resulted in a pronounced
reduction in serum levels of urea, creatinine, Na+ and K+ ions reaching
approximately to the normal values of control rats. The NO2- and NO3-
renal tissue contents were also decreased in a similar manner reaching a
comparable levels to the control values.
The results highlighted the important role of NO in AR?, and the possible
mechanism of carved ilol as a renoprotective agent through its modification
to the renal NO |
