The protective effect of adenosine (1 mg /kg LP.) in hepatitis induced
experimentally in rats with d-galactosarnine (800 mg /kg I P.) was assessed.
The degree of protection was determined biochemically by measuring
AST. ALT and bilirubin in addition to hepatic nitric oxide, and by
histo-pathological examination of liver.
In cbigalactosamine (nth , ed hepatitis in rats, there were significant elevation
of ALT, AST, bilirubin and NO2 and NO3 in addition to foci of necrosis
and infiltration of lymphocytes in hepatic lobules and portal tracts .
In rats treated with adenosine (ling /kg LP.) there were significant reduction
of ALT, AST, bilirubin and NO2 and NO3 in addition to more or
less normal histological picture of liver.
In conclusion, these findings revealed that acirmosine had a protective
anti-inflammatory effect on liver and this effect may be due to a reduction
of hepatic nitric oxide. |
