The effect of Tianeptine (Img/ kg 13.W. LP.) on cortical acetylcholine
and serotonine in experimentally induced hyperalgesia in rats by 1% Carrageenin
(25 ul, Lpl.) was made to evaluate the possible analgesic effect
of Tianeptine.
Results of the present work revealed that hyperalgesia resulted in significant
elevation of cortical acetylcholine and reduction of cortical serotonine
levels. Moreover. Tianeptine (1mg /kg B.W. I.P.) pretreated hyperalgesic
rats resulted in significant elevation of both acetylcholine and
serotonine levels in rat s cerebral cortex which may account its analgesic
effect.
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