The present study aimed to investigate the possibility of
cardioprotective effect of bisoprolol, recently introduced vasodilator f3-
adrenoceptor antagonist, against isoprenaline-induced acute myocardial
infarction in hypercholesterolemic rats. Acute hypercholesterolemiainduced
experimentally in male albino rat using 2% cholesterol-enriched
chow diet for feeding them for one month.
Twelve hypercholesterolemic animals were subdivided into two
groups: bisoprolol-treated group (n = 6) and saline-treated rats were (n =
6). Saline-treated non hypercholesterolemic rats (n = 6) were used as a
control group for the both hypercholesterolemic groups.
All rats underwent experiment myocardial global ischemia using a
high i.p. single dose of isoprenaline. Serum creating kinase activity,
electrocardiographic changes and myocardial infarct size area are three
indices were used to estimate the extent of myocardial damage.
The cardiac damage in hypercholesterolemic rats was much greater
than control diet fed rats. Bisoprolol treatment for one month showed
cardioprotective effect against isoprenaline-induced ischemia.
Acute hypercholesterolemia exaggerated the severity of myocardial
damage and bisoprolol montherapy treatment expressed a
cardioprotective effect against acute ischemia even in
hypercholesterolemic conditions. |
