Renal ischemia-reperfusion injury constitutes the most common
pathogenic factor for acute renal failure and is the main contributor to renal
dysfunction.
Thymoquinone (TQ) is the main active constituent of Nigella Sativa
seeds, black seed has an extremely high superoxide anion radical scavenging
ability.
An anaesthetized rat model of unilateral renal artery occlusion for the
study of ischaemia—reperfusion injury were used. Measurement of creatinine
for the examination of renal function, and measurement of superoxide
dismutase and lipid peroxides for examination of antioxidant evaluation.
In the present work, unilateral R/I caused significant increase in
serum creatinine.Also, SOD and lipid peroxidation worsened in the FR nontreated
left kidney .TQ given 60 minutes before left renal artery occlusion
improve significantly both serum creatinine and antioxidant parameters. |
