The renin-angiotensin system plays an important role in the regulation of
cardiovascular, renal, and endocrine functions. Local functional renin-angiotensin
systems (RAS) have been demonstrated in many organ and tissue systems.
It was found that the angiotensin II receptor blockers (ARBs) suppressed the
development of severe arthritis and joint destruction in the collagen-induced arthritis
model. These findings suggest that ARBs may have therapeutic potential in
rheumatoid arthritis.
All animals (30 male rats) were subjected to measurements of the hind paw
thickness and pressure threshold by using analgesymeter. Subsequently, Freund's
adjuvant was injected into the base of rat-tail. Sixteen days after administration of
Freund's adjuvant, animals were again subjected to the previously mentioned tests
and were randomly assigned to 3 groups:
I) Control group (II) candesartan cilextil Treated group (III) celecoxib treated group
All animals were subjected to the previous tests at days 15,30 after starting
treatment, then all animals were scarified, following scarification, the stomachs were
removed. Gastric contents were collected for evaluation of biochemical parameters.
The stomachs were opened along the greater curvature and the gastric lesions were
evaluated for identifying the ulcer index.
In this work candesartan cilextil and celecoxib showed significant beneficial
effect (anti-inflammatory and analgesic) compared to arthritic control non-treated
group. |
