Thirty mature albino rats were divided into
three equal groups. Amitriptyline (4.5 mg/kg),
amineptine (9 mg/kg) and distilled water were
given orally and daily for a period of 12 weeks
to rats of the first, second and third groups
respectively. Histopathological examination of
rat's livers revealed pictures of cholestatic
hepatitis in amitriptyline group and microvesicular
steatosis in amineptine group. Values of
biochemical parameters (total bilirubin, alkaline
phosphatase and ALT & AST enzymes) were all
significantly elevated with amineptine. With
amitriptyline, only total bilirubin and alkaline
phosphatase values were significantly elevated
while the increase in ALT and AST values were
not significant.
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