The present work aimed to clarify and investigate the beneficial or toxic
effects of some commonly used natural compounds; Royal Jelly, Nigella
sativum ( Baraka oil ) , Allium sativum ( garlic oil) and Omega - 3 fatty
acids . Their effects on long - term administration in male albino rats fed
high cholestrol diet for two months were studied. The effects investigated
were their actions on blood lipid profile ; total cholesterol (TC ), triglycerids
(TG) , high density lipoproteins (HDL)and low density lipoproteins
( L D L) as well as their histopathological effecti on blood vessels versus
the com-monly used antiatherosclerotic drug; bezafibrate . Also their effects
on some biochemical parameters ; liver function tests ( as serum albumin,
serum bilirubin , A L P, SGOT and SGPT ) and kidney function tests
( as serum creatinine and urea) were investigated.
The effects of these compounds on the immune system were also investigated
by measuring the T- lymphocyte and IgG titres.
Animals were divided into 7 groups ( each was 10 rats) ; normal group
( fed only standard diet for 2 months ) , atherosclerotic group ( fed high
cholesterol, 100 mg/kg / day p .,o) for two months , other five groups
fed high cholesterol diet for 2 months and oral Royal jelly ( R . J) ,Nigella
sativum ( N. S ) , Omega- 3 fatty acids, garline and bezafibrate
respectively.
From the results of this study it can be concluded that all compounds
used had a significant protective effect on the lipid profile and blood vessels
and can be used in prevention of progression and development of atherosclerosis
. It was found also that these compounds have a beneficial effect
on the immunity system as they have an immunostimulant effect except
Omega 3 - fatty acids ( which have an inununosuppressant effect) on long
term administration. |
