Background Dipeptidyl peptidase-4 (DPP4) enzyme inhibition has
been reported to increase plasma glucagon-like peptide-I (GLP-I)
level for controlling postprandial glucose concentration. DPP4
inhibitors have received attention for the potentiar, of these
inter \ entions to positively impact on cardiovascular outcomes. The
aim of the present study was to explore the potential protective effect
of PPP-4 inhibitor on acute myocardial infarction induced
experimentally in rats and possible mechanism of action. Material and
methods Severity two albino rats were divided randomly into 3 equal
groups: normal control group rats were received physiological saline.
Mwcardial infarction groups pretreated with vehicle or sitagliptin
(5mg:kg/day. orally by gastric gavage once a day) for 2 weeks before
len coronary arter> ligation for induction of acute myocardial infarction model in rats. Four
hours after, ligation of the left anterior descending coronary artery (LAD), the
electrocardiogram, blood pressure. cardiac enzyme (CPK). myocardial tumor necrosis factor
alpha I NI—u). and lipid perosidation as malondialdehyde level in the cardiac tissue were
measured. Additionally. glutathione peroxidase and catalase were determined before and after
myocardial in Enetion in all groups. in addition to histopathological examination. Results the
induction of m)ocardial inEuction resulted in highly peaked T wave in the ECG tracing;
significant increase in serum (TIC level, significant elevation of lipid peroxidation and INFcontent
ot the myocardial tissue compared with control group. On, the other hand,
glutathione peroxidase and catalase ‘‘ere decreased. Pretreatment with sitagliptin
(5nig/kgilda). orally) 2 weeks before ligation of LAD resulted in a significant decrease in peaked I \\ ave. insignificant decrease of blood pressure, pronounced reduction in serum CPK
level. reduction of myocardium lipid peroxidation and TNF-ct content level in myocardial
tissues. While, myocardial glutathione peroxidase and catalase contents were significantly
increased. I listopathological changes were supported with biochemical changes. Conclusion
the results highlight the efficacy of sitagliptin as cardioprotective drug against myocardial
infarction by improving inflammatory status and oxidative stress. |
