The effect of acute myocardial infarction (AM1) on some proinflammatory cytokines, as well as their relationship to serum lipids needs to be clarified. The current work was carried on 45 male subjects. Their ages ranged from 43-56 years They were 25 patients with AMI compared with 20 healthy subjects matched for the same age and sex as controls. For all subjects, serum interleukin-I (1L-1), interleukin-6 (1L-6) and tumor necrosis factor —alpha (TNFa) and lipid profile were assayed 24 hours post infarction and 6 weeks later on.
The results of this work showed that serum IL-1, IL-6 and TNF-a were significantly increased 24 hours post infarction and 6 weeks later compared with the control group (P<0.05). However, serum IL-I, 1L-6 and TNF-a were significantly decreased 6 weeks later after the onset of infarction compared with the same parameters 24 hours post infarction (P1 <0.05). |
