Background; Cytokines are involved in a wide spectrum of immune and non-immune biological events causing neonatal respiratory distress, as early onset neonatal sepsis. hyaline membrane disease (HMD) and transient tachypnea of newborn (TIN). Objectthes:To investigate if early detection of serum level of interleukin-6 (IL-6) .total leucocytic count (TIE), immature to total neutrophils ratio (I/T) and platelet count ,could distinguish early onset sepsis from other causes of respiratory distress in the newborn as HMD or TTN.Subjects: This cross sectional case-control study included 60 infants, classified according to physical examination and laboratory work into 4 groups: group A ,included 15 newborn with sepsis, 9 males and 6 females, their mean gestational age was 38.13+1.64week, and their mean weight was 3.806+1.16kg. Group B, included 15 newborns with TTN, 11 mnitos and 4 females, their mean gestational age was 39.1+1.2week and their mean weight was 3.81-.t0.12 kg. Group C. included 15 preterm with HMD, 7 males and 8 females, their mean gestational age was 32.6+1.92 week and their mean weight was 1.65+0.36kg Also, 15 full term neonates, 5 males and 10 females, their mean gestational age was 39.6+0.84week, and their mean weight was 3.61+ 0.23, served as a control group. Methods: All cases were subjected to the following: Complete blood Count, C reactive protein, serum level of 1L-6 and chest Xray. Results: The results of this study showed a highly significant increase in the mean serum level of IL-6 in the septic and TTN groups when compnred with control group (P<0.01). A highly significant increase in serum level of IL-6 in the septic group when compared to TIN group (P<0.01), while in HMD group |
