To elucidate the role of T lymphocyte activation and eosinophilic infiltration in the bronchial tree of patients with bronchial asthma and the effect of salbutamol and anhydrous theophylline on these pa. 10111C1M, a study was carried out on twenty patients having extrinsic asthma (group I), twenty with in- whole asthma (group Wand ten healthy controls (group Soluble Interleukin-2 receptors (sIL-2R). eosinophilic count both in bronchoalveolar lavage (SAL) and blood were performed immediately after ! the relief of acute attack and one week later during remission. Physiologic parameters including FEV , FVC and PEFR were also done during acute attack and 20 minutes after inhalation of nebulized sal- , botanic!. Each group of asthmatic patients were divided into two subgroups, group la and group Ha re- ceived salbutamol and group lb and group Jib received anhydrous theophylline. The mean serum and SAL sIL-2R and eosinophilic count were significantly higher in acute episode of asthma compared to ; normal comrols, moreover, there was a positive correlation between sIL-2R and eosinophilic count with an inverse relationship with PEER. Seven days after the acute attack, patients received salbutamol did not show any significant decrease in either sIL-2R or eosinophilic count in SAL fluid and blood, on the other hand significant reduction was observed in patients receiving anhydrous theophylline. Therefore. it could he concluded that T cell activation with increased eosinophilic infiltration in bronchial tree may lead to enhanced bronchial hwerreactivity in patients wit:. ,.7ronchial asthma, anhydrous rheaphylline possesses andinflamntatory action by virtue of its inhibitory effect on T lymphocyte activation |
