Avidity ELISA is an uprising method developed to discriminate between
acute and chronic infections. The usefulness of this technique was tested on
143 sera screened for specific antitoxoplasma IgM and IgG antibodies using
conventional ELISA. Of the 10 sera found IgM and IgG positive, only one
(10%) showed low IgG avidity index (Al) indicative of acute Toxoplasma
infection (P<0.05). Out of 63 sera found positive for specific antitoxoplasma
IgG only, 60 (95.2%) showed high IgG avidity index, indicative of chronic
infection. In conclusion, IgG avidity ELISA might facilitate more accurate
diagnosis of acute Toxoplasma infection in pregnant women, particularly in
Egypt where Gynecologists depend on a single serum sample in
serodiagnosis of acute toxoplasmosis. Based on this additional information,
many women will avoid repeated testing, unnecessary examinations,
treatment and anxiet |
