This study is a trail to find out any association between helicobacter pylori (HP) infection and coronaryheart disease. A total of fifty subjects were included, forty ofthemwere patientswith coronary heart disease taken as astudy group and ten healthy persons were chosen as a control group. The study groupwas subdivided into two subgroups : subgroup A comprised thirty patients with myocardial infarctionfollowedby angina and subgroup B included 10 patients suffered from angina only. All patientswith coronary heart diseasewere non smokers and none of them had known risk factors as diabetes mellitus, hypertension, hyperlipidaemia and hypenrricaemia. Laboratory investigations, electrocardiographic study, serologic examination for detection ofHPwere done for all subjects. Upper endoscopy followed by gastric biopsy and histopathologic examinationwere performed only for seropositive cases.
Serplogic examination for HPwas positive in 75%in coronary heart disease patients compared to 40% of the control cases. The percentage ofHP infection in infarction and angina subgroupswas 76.6%and 70%respectively, 64.67% of patients with coronary heart disease showed severeHP infection and 53.33%showed moderate infection. All cases with severe infection were suffering from myocardial infarction. It could be concluded thatHelicobacter pylori infection might play a considerable role in the pathogenesis of coronary heart disease and therefore, eradication of helicobacter pylori infection by proper antibiotic therapymight be of good prophylactic value against coronary heart disease. |
