Publications of Faculty of Medicine:E-SELECTIN AND INTERCELLULAR ADHESION MOLECULE-1 SERUM CONCENTRATION IN DIABETIC PATIENTS: INFLUENCE OF GLYCEMIC CONTROL, OXIDATIVE STRESS AND INTERFERON-GAMMA: Abstract

To investigate the serum level of soluble E-selectirt and intercellular adhesion molecule-I (ICAM-I) in diabetes mellitus and the possible factors affecting it, we studied 40 IDDM patients (20 males, 20 females, 25.9 + 7.8 years old) and 40 NIDDM patients (20 males. 20 females, 52.5 + 10.8 years old). Twenty healthy subjects (10 males, 10 females, 32.3 + 6.8 years old) served as controls. Twenty five patients had good metabolic control, whereas the remaining 55 patients are poorly controlled. Patients who had liver disease, overt nephropathy or any pathological processes known to affect adhesion molecules are excluded from the study. Detailed history. clinical examination and the following laboratory investigations were performed to every subject: plasma glucose (fasting and postprandial), glycosylated hemoglobin (Hb Al c), serum creatinine, serum level of malondialdehyde (a marker of oxidative stress), serum level of soluble cell adhesion molecules (E-selectin and ICAM-I). LFN yfrom lymphocyte culture (a marker of T-cell activity) and urine analysis with special stress on microalbuminuria