Cerebral strokes are group of serious diseases that affect the central nervous system. Antibodies directed against
phospholipids are highly associated with many venous and arterial thrombotic episodes. Anticardiolipin antibodies (ACA) (1gG, IgM andIgA) are one of these. Aim of work: to study the incidence of ACA in patients with
cerebral strokes for better etiological and prognostic criteria of this serious disease.
Methods: 22 patients suffering from cerebra vasclas strokes, as evidenced by clinical picture and CT brain scanning, were subjected to full laboratory investigations including ACA levels, detected by EL1SA technique.
Results: 22 patients with stroke were included in this study. Fourteen were males and 8 females with mean ages 46.07 + 13.22 and 50.8 + 9.4 respectively. Seventeen patients were seen in their first attack and the remaining 5 in their second one. IgM and IgG levels of ACA were statistically significant in all patients in comparison to control group. Mean levels of IgM and IgG in patients in their first attack were 4.99 + 2.43, 14.21 + 11.98 in comparison to those in 2nd attack, 2.41 + ,85, 7.2 + 3.39,respectively. Female patients showed higher levels of IgM and IgG antibodies in comparison to males being 5.213 + 1.192 and 17.145 + 15.991, 3.946 +2.846 and 10.058 + 6116 respectively. Conclusion :Measuring ACA level in patients with stroke is a valuable laboratory test, which may carry certain diagnostic and+A90 prognostic importance including prevention of recurrence of such serious
disease. |
