his study included 26 patients with HCC and 20 controls. Liver
biopsies histopathological grading of HCC defined 13 patients with well
differentiated, 7 with moderately differentiated and 6 with poorly
differentiated HCC. Serum levels of these parameters were significantly
higher in patients compared to controls and in patients had poorly
compared to patients had well differentiated HCC. Serum of Des-Ycarboxyprothrombin
(DCP) and total AFP concentration (AFP-L3%) were significantly higher in patients had
poorly compared to those had moderately differentiated HCC, but
serum DCP AFP and AFP-L3% levels were not-significantly higher in
these respects. Stepwise regression analysis defined serum DCP levels,
alone or in combination with other markers, as a significant predictor for
the extent of pathological advancement in 3 models of
statistical analysis. In conclusion, a panel of DCP
and AFP-L3% provided a high noninvasive diagnostic yield for HCC and
prediction of its pathological grading especially in compromised or early
staged patients. |
