This study was carried out on twenty patients with acute myocardial infarction (10 had anterior and 10 had inferior infarction) in a trial to find out any relationship between plasma fibronectin level and severity of myocardial infarction. Plasma fibronectin wassignificantly reduced on the 1st, 2nd, 3rd and 81h postinfarction days
and raised by the 20th day. However, Marked diminution was more noticeable in anterior compared to inferior infarction. Plasma fibronectin positively correlated with the ejection fraction and
fractional shorteni ng and negatively correlated with the level of cardiac enzymes, with leucocytosis and ES!? and with the size of infarction. Therefore, the degree of diminution of plasma fibronectin
can be considered as a parameter reflecting the severity of myocardial involvement. On the other hand its rise signifies myocardial healing. However, trial for evaluating the therapeutic efficacy of exogenous
fibronectin in promoting healing of acute myocardial infarction might be recommended as a future research. |
