The study was conducted on ten adult male partients with chronic renal failure on
regular haemodialysis as well as ten normal healthy control subjects, with matching
age and sex. all patients were subjected to complete clinical and laboratory investigation
to diagnose renal failure and exclude other diseases that alter lipid metabolism.
All patients and controls were subjected to the following:
I- Estimation of urea and creatinine in scrum.
2- Estimation of serum levels of oiglycerides, total cholesterol, HDL-c, LDL-c,
VLDL-c and apolipoprotein B. Results of this study showed that chronic renal failure
patients on regular haemodialysis had disturbed lipid metabolism. They had their serum
cholesterol within normal levels. The serum levels of their triglycerides (TG),
low-density lipoprotein (LDL), very-low density lipoprotein (VLDL) and apolipoprotein-
B (Apolipo-B) were higher than normal control cases while their high density lipoproteins
(HDL) serum levels were below that of the normal control cases. Haemodialysis
does appear to modify lipoprotein abnormalities observed in patients with
chronic renal failure undergoing maintenance haemodialysis as only serum levels of
low density lipoproteins (LDL) showed return to normal levels by continuity of the
dialysis. We concluded that these abnormalities in lipoprotein composition may be responsible
for increasing risk for cardiovascular atheromatous disease in regular haemodialysis
patients. |
