The present study investigated the effect of dialyzer reprocessing on
leucocytes and on complement activation in 10 uremic patients undergoing
chronic hemodialysis by determing the total & differential leucocytic count and
complement 3 level on using new and reprocessed dialyzers, before dialysis,
after 20 minutes and at the end of dialysis. The relation between these changes
& what is called "first use syndrome" was also studied.
The results showed that there was significant granulocytopenia during the
initial phase of hemodialysis which was more on using reprocessed dialyzer.
Also the study showed significant complement activation during the initial
phase of hemodialysis which was less on using reprocessed dialyzer. This
attenuation of complement activation with usage of reprocessed dialyzer was
accompanied with disappearance or at least, improvement of the manifestations
of "first use syndrome" in hemodialyzed patients. |
