Eighty subjects (60 patients with chronic renal failure (CRF) under different method of
therapy, in addition to 20 healthy normal control subjects) were included in this study.
They were subdivided into the following groups. Group I: included 20 normal healthy
subjects as controls. Group : included 20 patients of CRF under conservative treatment.
Group III: included 20 patients of CRF under Izaemodialysis (HD). Group IV: included
20 patients of CRF under chronic peritoneal dialysis (CPD). For all groups serum lipid
profile was done including serum triglycerides, total cholesterol, HDL-C, LDL-C, HDL-C/
LDL-C ratio, ApoA, ApoB, ApoA/ApoB ratio and Lipoprotein (a) (Lp(a)), And we get the
following results:
- There was a significant increase in serum triglycerides in different groups of CRF under
different methods of therapy (conservative treatment, lzaemodialysis and chronic peritoneal
dialysis) (P < 0.001 for all).
- There was a significant increase in total serum cholesterol in patients with CRF under
chronic peritoneal dialysis (P < 0.001), but non significant changes in the conservative
treatment (P > 0.05) and haemodialysis (P> 0.05) groups.
- There was a significant decrease in HDL-C in all the studied groups of CRF under
different methods of therapy (P < 0.001 for all).
-
There was a significant increase in LDL-C in CRF patients Under CPD (P <0.001,
and non significant chnages in its level in the conservative treatment and HD groups (P>
0.05 for both).
- There was a significant decrease in HDL - C/LDL-C ratio in all groups of CRF under
different nzethods of therapy (conservative treatment (P < 0.001), HD (P < 0.01) and CPD
(P <0.001)).
- There was a significant decrease in ApoA in all groups of CRF under different methods
of therapy (P 0.05 for
both). |
