This work was carried out on 24 patients suffering from acute chest
pain suspicious of acute myocardial infarction ( AMI ) and 10 well
matched normal controls . Patients and controls had undergone electro-
cardiographic monitoring ( ECG ) , determination of serum creatine
phospholcinase ( CPK) and serum myoglobin by turbidimetric immunoassay.
Out of these 24 patients 9 proved to have unstable angina and
15 had AMI . Eleven patients were admitted within 24 hours and
13 within 6 hours from the onset of chest pain . Out of these 13 patients
only 9 had AMI . Sensitivity of myoglobin , CPK and ECG
in all patients with AMI was 86.8% , 60% and 66.6% respectively .
The sensitivity of myoglobin and CPK in AMI patients admitted within
6 hours was 88.8% and 33.33% , respectively . The specificity
for myoglobin , CPK and ECG in all ANTI patients was 100% . Therefore
serum myizolobin assay by immunoturbidifietric method can be
considered as a sensitive and specific test to diagnose AMT in the first ral
few hours and also io identify those patients without definite ECG
changes. |
