The aim of this work ,was to evaluate plasma Ang H level in essential
hypertensive patients and to verify its relation to the presence and
severity of coronary artery disease.
Fifty eight patients with essential hypertension and ischaernic chest
pain (group A) together with twelve healthy normotensive volunteers
(group B) were included in this study.Thorough clinical examination,
resting ECG. plain chest X ray, routine laboratory investigations,
angiotensin H (Ang 1) serum level and echo-Doppler were done for all
individuals.Coronary angiography was done fore the group A patients
only. The statistical analysis of the results pointed out, a significant higher
level of Ang H in group A(38.3 + 2 pmol/ L) than in groupB (24.9 + 9
pant/ L)and that its level in group A patients were positively correlated
significantly to left ventricular mass index and left ventricular wall motion
score index but negatively to E/A ratio. Ang H level was significantly
higher in hypertensive patients with coronary artery disease (group AID
(59.1 + 2 prnol/L) than those with normal coronaries (groupA 1)(31.9 + 1
pmol/L). Group All patients with three vessels disease had a significantly
higher Ang H level than those with two or one vessel coronary artery
disease. Ang H level was significantly higher in group All patients with
LAD coronary artery lesion than those without
Conclusion:Patients with essential hypertension had a significantly
higher Any II level than norrnotensives.Ang II level was positively
correlated significantly to the presence. number and severity of coronary
artery lesion in hypertensive patients.Patients with LAD lesion
signficantly hod a higher Any If level than those without |
