To determine the relationship between angiographically defined coronary
artery disease (CAD) and serum lipids and lipoproteins, and to determine
the value of this risk factor in predicting the presence of CAD in
patient who will undergo coronary angiography, 80 patients with stable
angina - hail of them have had hyperlipidemia and the rest were normolipidemic
- were subjected to full medical history, thorough medical examination,
12-lends ECG. laboratory investigations for C-reactive protein
(CRP), lipids and lipoproteins profile and coronary angiography.
The results of this study showed that:
The most predictive value of all serum lipids for the presence of significant
lesions of the coronary arteries was the ratio of total cholesterol to
high density lipoprotein cholesterol (TC/ HDLC) which had the best sensitivity,
specificity, positive predictive value (PPD), and negative predictive
value (NPV).
There is no significant difference between the two studied groups as
regards number or type of vessels, site of lesions or type of lesions.
The level of C-reactive protein (CRP)-which is a marker of systemic inflammation
- is increased in patients with stable angina and this increase
is more marked with hyperlipidemia.
C-reactive protein (CRP) can predict the presence of significant lesions
in patients with stable angina documented with angiography.
Adding the predictive value of TC / HDLC to CRP level found more
valuable in prediction of occurrence of a significant coronary artery lesion. |
