This study was carried out on twenty patients with acute
myocardial infarction (10 had anterior and 10 had inferior infarction)
in a trial to find wit any relationship between plasma fibronectin level
and severity of myocardial infarction. Plasma fibronectin was
significantly reduced on the 1st, 2nd, 3rd and 8th postinfarction days
and raised by the 201h day. However, Marked diminution was inure
noticeable in anterior compared to inferior infarction. Plasma
fibronectin positively correlated with the ejection fraction and
fractional shortening and negatively correlated with the level of
cardiac enzymes, with leucocytosis and ES!? and with the size of
infarction. Therefore, the degree of diminution of plasma fibronectin
can be considered as a parameter reflecting the severity of myocardial
involvement. On the other hand its rise signifies myocardial healing.
However, trial for evaluating the therapeutic efficacy of exogenous
fibronectin in promoting healing of acute myocardial infarction might
be recommended as a future research. |
