Eighty subjects (60 patients with chronic renal failure (CRF) under
different methods of therapy, in addition to 20 healthy normal control
subjects) were included in this study. They were subdivided into the
following groups. Group I: included 20 normal healthy subjects as controls.
Group II: included 20 patients of CRF under conservative treatment. Group
Ill included 20 patients of CRF under haemodialysis (HD). Group IV
included 20 patients of CRF under chronic peritoneal dialysis (CPD). For all
groups serum lipid profile was done including serum triglycerides, total
cholesterol, HDL-C, LDL-C, HDL-C/LDL-C ratio, ApoA, ApoB, ApoA/Apo B
ratio and Lipoprotein (a) (Lp(a)). And we get the following results:
- There was a significant increase in serum triglycerides in different
groups of CRF under different methods of therapy (conservative treatment,
haemodialysis and chronic peritoneal dialysis) (P <0.001 for all).
- There was a significant increase in total serum cholesterol in
patients with CRF under chronic peritoneal dialysis (P < 0.001), but non
significant changes in the conservative treatment (P > 0.05) and
haemodialysis (P > 0.05) groups.
- There was a significant decrease in HDL-C in all the studied groups
of CRF under different methods of therapy (P <0.001 for all).
- There was a significant increase in LDL-C in CRF patients under
CPD (P < 0.001), and non significant changes in its level in the
conserevative treatment and HD groups (P > 0.05 for both). |
