The adhesion molecules ICAM-1 and VCAM-1 are regulated by proinflammatory
cytokines and play an important role in the binding and activation of leucocytes in
inflammatory diseases. They have been recently detected in serum of patients with
chronic renal failure. This study measures the serum concentration of circulating
adhesion molecules (cICAM-1 and cVCAM-1) and tumor necrosis factor alpha (TNF-a)
before and after hemodialysis by ELISA technique. Before hemodialysis, both cICAM-1
and cVCAM-1 and TNFa levels were significantly elevated when compared to their
levels after hemodialysis. Also before hemodialysis, their levels were significantly
higher when compared to control group but after hemodialysis their levels in CRF
patient were still elevated but not significant when compared to levels in control group.
Moreover, the level of TNFa correlate with the level of cICAM-1 and cVCAM-1 before
and after hemodialysis. This suggests that TNFa plays a role in expression of these
adhesion molecules that may play a role in perpetuation for infection and inflammation
that appear during the course of chronic renal failure. Also, this study shows the
benificial effect of HD in decreasing the level of these nocuous adhesion molecules. |
