Diabetic nephropathy is characterized by excessive urinary
excretion of certain proteins, which is thought to be related to changes in
glomerular permeability. Several studies found that increased urinary
albumin excretion rate is a sensitive indicator for early diabetic
nephropathy. But, earlier indicators of impending diabetic nephropathy
are needed, these are unlike microalbuminuria, would predict the
subsequent development of diabetic nephropathy but instead the earliest
sign of the nephropathy, haptoglobin used as a predictor in this study for
patients with diabetic nephropathy and non nephropathic patients. In our
study, there was a significant difference of haptoglobin level between
patients and controls. Also, there is a significant difference between
nephropathic and non nephropathic group. Also, there was a significant
difference between macroalbuminuric, microalbuminuric and
normolbuminuric groups. |
