Helicobacter Pylori (H.P.) has been found in gastric biopsy speciemens
and linked to many diseases in the gastrointestinal tract (GIT).
II.P. infection of the gastric mucosa is regarded as the major etiological
agent in chronic diffuse, superficial gastritis and an important risk factor
for the development of intestinal type of gastric carcinoma. Forty
patients were included in this study (22 men and 18 women). Patients
showed variant forms of endoscopic readings ranging from normal finding,
to severe gastritis or duodenal ulcer. Twenty four patients (24/40)
Proved to be Helicobacter Pylon (HP) positive by rapid urease test
(60%). Eighteen patients of them (18/24) were gram +ve (75%). Patients
showed bile reflux with bile acid > 1 mmo1/1 were 24 (24/40) of
total (60%) , 19 of them were IIP positive by rapid unease test (79.1%)
(p < 0.05). Sixteen patients of them were also Gram -i-ve for H.P. Those
16 patients which were DGR +ve. unease +ve and Gram +ve were subjected
to treatment protocol of triple therapy for 2 weeks. Follow up was
done after one month of the end of treatment. Ten patients with DGR
showed marked reduction in bile acid concentration (< 1 rnmol/L) while
the rest showed no changes. Thirteen patients became H. pylon -ve. All
DGR -ve patients became H. pylori -ve (p > 0.05). Histopathological
examination of antral biopsy showed no inflammatory responses in 8
patients after eradication of II. pylori (n = 13) ( p < 0.05). |
