The aim of the present study is to examine the relationship
between blood pressure, leptin and plasma
renin activity in normotensive healthy volunteers and
in lean non-diabetic patients with essential hypertension.
Our work was carried out on 80 subjects
classified into 2 groups. Group I included 50 lean nondiabetic
patients with mild to moderate essential hypertension
(age: 38.5+ 1.8 years, BMI: 21.7+ 2.5 kg/
m2, male/female: 25/25). Group II included 30 lean
normotensive healthy subjects (age: 39.4+ 2.2 years,
BMI: 21.9+ 2.5 kg/m2, male/female:15/15). Both
groups were properly matched for age, sex and BMI.
After the blood pressure measurements, blood samples
were collected for the assessment of leptin, renin
activity, glucose and creatinine.
No significant differences in age, BMI, plasma glucose
and serum creatinine were detected between
group I and group II subjects. Howevere, blood pressure
(systolic and diastolic), plasma leptin levels and
plasma renin activity (PRA) were significantly higher
in group I patients than in group II subjects (p<0.05).
Blood pressure, age, BMI, serum creatinine and PRA |
