The work was carried out on 20 patients with acute myocardial infarction
in order to study the effect of lidocaine on the urine outflow, sodium
and potassium excretion . Lidocaine was given in a dose of 1 mg /kg
body weight as intravenous bolus over one minute. Urine was collected
from every patient one hour before and every30 minutes over a period of
3 hours after drug administration . venous blood samples wcre withdrawn
one hour before and two hours after. It was noticed that lidocaine
has marked antiduretic, natriuretic effect and increased potassium excretion
at 30 to 60 minutes after drug administration, the maximum effect
was observed at 90 to 120 minutes , gradual decline was recorded at
120 to 150 minutes, continuous decrease was seen at 150 to 180 minutes
and become non significant from that before drug administration. |
