Objectives: the purpose of this study was designed to evaluate the
prognostic value of estimation of serum E-selectin in type II diabetic patients
in a trial to correlate its level with their glycemic control and renal
angiopathic complications. Backgrounds: Diabetes is characterized by
many complications where the most important complications are the vascular
ones in the form of microangiopathy and atherosclerotic changes
such as nephropathy, retinopathy and neuropathy. The level of soluble
form of E-selectin has been detected increased in sera of patients with
type II diabetes mellitus where in type 2 DM there is increased endothelial
dysfunction and chronic inflammation. Increased serum levels of cell adhesion
molecules may be pathognomonic for diabetic microangiopathic
changes in diabetic patients.
Methods: This study was carried out on 45 patients with type 2 diabetes
mellitus and 15 apparently healthy volunteers as a control group.
The patients groups were divided into 3 groups according to the presence
of protein in urine, group 1(15 patients) whose were normoalbumirturic,
- group II (15 patients) whose urine revealed the presence of microalburninuric
and group III (15 patients) whose urine showed macroalbuminuric.
Serum soluble E- selectin was measured by quantitative sandwich enzyme
imrnwioassay technique in all subjects. |
