This study included three groups of subjects: group (A) comprised 15 Insulin
dependent diabetics, group (B) comprised 15 non-Insulin dependent diabetics
and group (C) comprised 15 Normal healthy subjects (Control).
All of them were subjected to a thorough history taking, clinical examination,
fundus examination, plasma fibronectin level, fasting and two hour
postprandial blood glucose. In conclusion we found that plasma fibronectin
levels were higher in all diabetic groups with or without diabetic microangiopathy
compared to control group (diabetics as whole, type - I diabetics,
type II diabetics, diabetics with retinopathy and diabetics with
diabetic foot ). Also plasma fibronectin levels were found higher in patients
with diabetic retinopathy compared to those without retinopathy
and higher in patients with diabetic foot compared to those without diabetic
foot which agrees with the theory suggesting that plasma fibronectin is
higher in diabetic microangiopathy. Plasma fibronectin concentration exhibited
no significant correlation with fasting or two hour post prandial
blood glucose or duration of diabetes. So fibronectin might be considered
as indication of microvascular damage in diabetes mellitus and can represent
an important approach in the study and prevention of diabetic microangiopathic
disorders. |
