Eighty subjects (60 patients with chronic renal failure (CRF) under different methods of
therapy, in addition to 20 healthy normal control subjects) were included in this study.
They were subdivided into the following groups. Group I: included 20 normal healthy
subjects as controls. Group : included 20 patients of CRF under conservative treatment.
Group II!: included 20 patients of CRF under haemodialysis (HD). Group IV: included
20 patients of CRF under chronic peritoneal dialysis (CPD). For all groups serum lipid
profile was done including serum triglycerides, total cholesterol, HDL-C, LDL-C, HDL-C/
LDL-C ratio, ApoA, ApoB, ApoA/ApoB ratio and Lipoprotein (a) (Lp(a)). And we get the
following results:
- There was a significant increase in serum triglycerides in different groups of CRF under
different methods of therapy (conservative treatment, haemodialysis and chronic peritoneal
dialysis) (P <0.001 for all).
- There was a significant increase in total serum cholesterol in patients with CRF under
chronic peritoneal dialysis (P < 0.001), but non significant changes in the conservative
treatment (P > 0.05) and haetnodialysis (P> 0.05) groups.
- There was a significant decrease in HDL-C in all the studied groups of CRF under
different methods of therapy (P < 0.001 for all).
- There was a significant increase in LDL-C in CRF patients under CPD (P < 0.001,
and non significant chnages in its level in the conservative treatment and HD groups (P>
0.05 for both).
- There was a significant decrease in HDL - ULDL-C ratio in all groups of CRF under
different methods of therapy (conservative treatment (P < 0.001), HD (P < 0.0)) and CPD
(P <0.001)).
- There was a significant decrease in ApoA in all groups of CRF tinder different methods
of therapy (P <0.00) for all).
- There was a significant increase in ApoB in CPD group (P < 0.001) and non significant
changes in both the conservative treatment and haenwdialysis groups (P > 0.05 for
both). |
