This work was carried out on 24 patients suffering from acute chest
pain suspicious of acute myocardial infarction ( AMI ) and 10 well
matched normal controls . Patients and controls had undergone electro-
cardiographic monitoring ( ECG ) , determination of serum creatine
phospholcinase ( CPK ) and serum myoglobin by turbidimetric immunoassay.
Out of these 24 patients 9 proved to have unstable angina and
15 had AM1 . Eleven patients were admitted within 24 hours and
13 within 6 hours from the onset of chest pain. Out of these 13 patients
only 9 had AM! . Sensitivity of myoglobin , CPK and ECG
in all patients with AM1 was 86.8% , 60% and 66.6% respectively.
The sensitivity of myoglobin and CPK in AMI patients admitted within
6 hours was 88.8% and 33.33% , respectively . The specificity
for myoglobin , CPK and ECG in all AMI patients was 100% . Therefore
serum mygolobin assay by immunoturbidmetric method can be
considered as a sensitive and specific test to diagnose AMI in the first
few hours and also to identify those patients without definite ECG
changes. |
