In the present work we studied the fibrinolytic activity in diabetic patients
with and without nephropathy in a trial to find out the relation between
the fibrinolytic activity and diabetic nephropathy. This study included
60 subjects classified into 3 groups: Group 1: 20 healthy normal controls.
Group 2: 20 diabetic patients without nephropathy. Group 3: 20 diabetic
patients with nephropathy. Fibrinolytic activity of blood includes: 1.
Plasma fibrinogen level, b. Euglobulin clot lysis time, c. Serum fibrinogen
/ fibrin degradation products. The results of this work revealed:
(1) The mean plasma fibrinogen levels was higher in diabetics than that of
the control. Hyperfibrinogenameia was found in all cases with diabetic
nephropathy and in 55% of diabetic without nephropathy, (2) The mean
levels of serum fibrinogen / fibrin degradation products in the diabetics
was significantly higher than that of the control group, (3) The mean
euglobulin clot lysis time in the diabetics was longer than that of the
control.
The present study, showed that, fibrinolytic activity is depressed in
diabetic patients, and more so in diabetics with nephropathy. Such decreased
fibrinolytic activity favour hypercoagulable state and subsequent
thromboembolic complications. |
