In this study membrane lipid peroxidation in erythrocytes
fifteen diabetic patients and its correlation with plasma glucose was
studied. Diabetic patients were eight males and seven females.
Their ages ranged 20-45, with a mean value of 30 ± 3.5 years. Al!
patients in this study were insulin dependent diabetics, except 2 who
had non insulin dependent diabetes. Another fifteen healthy
subjects volunteered as controls. Their ages ranged 23-46 , with a
mean value of 29± 4.1 years. Lipid peroxidation was estimated by
quantitating malondialdehyde (NIDA), an end product of lipid
peroxidation. Erythrocytes of diabetics showed a significantly
higher (P<0.05) malondialdehyde level compared with non diabetic
erythrocytes. The degree of membrane lipid peroxidation in
erythrocytes was significantly correlated with the level of
glycosylated hemoglobin. ( r = 0.81, P< 0.05). This suggests that
peroxidation of membrane lipids and accumulation of MDA occurs
in erythrocytes of diabetic patients. |
