Aim of this work is to study calcium homeostasis in
essential hypertension through evaluation of calciotropic
hormones and their relations to ream level. Thirty hypertensive
patients and ten normal volunteer persons were included
in this study, patients and control were subjected to
full medical history and examination, complete urine examination,
fasting blood sugar, blood urea nitrogen, complete
blood picture, abdominal ultrasonography, serum
creatinine, serum potassium, serum sodium, serum calcium,
24 hours urinary calcium, serum 1,25 dihydroxy vitamin
D, serum parathyroid hormone (PTH) and plasma
renin activity. The results of this work showed no significant
differences between the mean serum calcium values
in the hypertensive group and the control group, a significant
elevation of 24 hours urinary calcium in the hypertensive
group when compared to the control group and a significant
elevation of the mean value of serum 1,25 (OH)2D
and serum PTH in the hypertensive group when compared
to the control group. No correlations were observed among
serum PTH, serum 1,25 (OH)2D and urinary calcium in
the hypertensive group. From this study we came to conclusion
that hypercalciuria is a major derangement of calcium
metabolism in patients with essential hypertension.
The elevated PTH and 1,25 (OH)211) might be a compensatory
response to restore calcium balance to normal, these
calciotropic hormones directly facilitate calcium transport
intracellaurly, intracellular calcium accumulation and
hence increase cytosolic free Ca-1* which is crucial for
vascular contractile activity and hence elevation of blood
pressure. |
