AIM: Overexpression of mucosa( metalloproteinases (MNIP) have been
demonstrated recently in inflammatory bowel disease. Their activity can
be counterbalanced by the tissue inhibitor of metallo'proteinases (TIM?).
The aim of this study was to evaluate the effect of ulcerative colitis (UC)
on MMP-1 and TIMP-1 plasma concentrations. as two possible biomarkers
of the disease activity.
METHODS: MM?-1 and T1MP- I plasma concentrations were measured
with an enzyme immunoassay in 16 patients with endoscopically confirmed
active UC and 12 healthy controls.
RESULTS: Plasma concentrations of both MNIP-1 (13.7+0.2 ng/ ml)
and TIMP-1 (799+140 ng / ma were signcantly elevated in UC patients
in comparison to healthy controls (11.9+0.9 ng/mL and 220+7 ng/ ml respectively).
There was no con-elation between TEMP-1 and MMP-1 concentrations
(r=-0.02). TIMP-1 levels revealed significant positive correlations
with scored endoscopic degree of mucosal injury. disease activity
index and clinical activity index values as well as C-reactive protein
concentration. There was no correladon between MMP-1 and laboratory.
clinical or endoscopic indices of the disease activity.
CONCLUSION: These results confirm the role of both MM?-1 and
TIMP-1 in the pathogenesis of ulcerative colitis. However only TIMID- I
can be useful as a biomarker of the disease activity, demonstrating as•
sociatiort. with clinical endoscopic pictures. |
