Abstract: The main goal of this study was to histologically evaluate the
healing of surgically created defects on the tibiae of adult rats after
implantation of bioactive glass. Twenty adult Wistar rats (body weight of 300g)
were divided into two groups:
bioglass treated group (n=10) and control group (n=10). Unicortical bone
defects with 3-mm diameter were performed in both tibiae of the animals and
filled with bioglass particles. The rats were then sacrificed at 14, 30 , 60 and
90 days, and the tissues were prepared for histological processing,
sectioning, and staining with hematoxylin and eosin, as well as Mallory
trichrome,and analyzed under light microscope. Within 7-14 days, both groups
presented connective tissue septa with new bone formation, more intense in
bioglass treated group. In the subsequent periods (30, 60 and 90 days), these
groups presented moremature bone tissue around the glass particles. Bone
trabeculae formed in all experimental periods were juxtaposed to the glass
particles. It can be concluded that bioglass materials promoted bone
formation over the entire extension of the defect, independently of the size of
the granules, thus confirming their biological osteoconductive property |
