This work was carried out on 10 healthy volunteers who served as a
control group (GO. and 50 patients with chronic renal failure. The uremic
patients were divided into 5 groups, each consisted of 10 patients.
Group 2 (02) comprised patients with negative HBsAg. Group 3 (G3)
comprised patients treated with conservative measures who are chronic
healthy carrier for HBsAg. Group 4 (G4) comprised patients treated with
conservative measures who suffered from chronic active hepatitis due to
HBV infection. Group 5 (05) comprised dialyzed patients who are
chronic healthy carrier for 1-1l3sAg. Group 6 (06) comprised dialyzed patients
who suffered from chronic active hepatitis due to HBV infection.
The following laboratory investigations were performed to all subjects:
complete blood picture, counting of T-lymphocytes, HBsAg, blood
urea, serum creatinine , serum bilirubin and serum transaminases. Diagnosis
of chronic active hepatitis was confirmed by liver biopsy.
Our study showed that chronic renal failure as well as haemodialysis
decreased significantly both total lymphocytic count and absolute T-cell
count.
Total lymphocytic count & absolute T-cell count showed significant
negative correlation with blood urea, serum creatinine, duration of dialysis,
and the age of patients. HBsAg positive uremic patients showed significant
reduction in absolute T-cell count, but didn't show significant
change in total lymphocytic count, when compared with HBsAg negative
uremlc patients. No significant difference could be found in both total
lymphocytic and absolute T-cell count between chronic active hepatitis
uremic patients and chronic healthy carrier uremic patients. Finally, no
significant correlation was detected between the biochemical parameters
of liver function (total serum bilirubin, SOOT and SGPT) and both total
lymphocytic count and absolute T-cell count. |
