This study was a trial to evaluate the potential value of scrum osteocalcin
(BGP) as a marker of bone turnover in elderly osteoporotic male patients
and to assess bone dynamics in elderly males via estimation of serum osteocalcin.
* Forty-five cases all were males. (15 middle aged normal control
cases, 15 elderly non-osteoporotic males and 15 males with senile osteoporosis)
comprised the material of this study. * For each case of this study;
full history, complete clinical examination laboratory investigations(ineluded
blood picture, stool and urine analysis, blood sugar estimation, renal.
and liver profile) for exclusion of any underlying disease, radiologic
study (X-ray spine) and estimation of scrum calcium, phosphorus, alkaline
phosphatase and serum osteocalcin, all were done. Serum osteocalcin
(BGP) was measured by the radioimmunoassay technique. Serum calcium
and phosphorus were normal in all subjects of this study. The study revealed
that both serum alkaline phosphatase levels and also, serum osteocalcin
levels increased with age, and the increase for these two parameters
was higher in the osteoporotic patients. Also, there was a significant correlation
between serum alkaline phosphatase in the elderly groups. We
found that scrum osteocalcin in the first group cases was 3.82±0.8 neml
and in the second group was 7.13t1.7 ml while it was 13.40±3.9 ng/ml in
the osteoporotic group. We may conclude that serial measurements of serum
osteocalcin in elderly individuals may be helpful in study of their bone
dynamics and early diagnosis of senile osteoporosis. |
